Author

D. A. Vignali

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. R. Cillo· 4 shared T. C. Bruno· 4 shared S. Onkar· 3 shared A. Morris· 2 shared A. Ray· 2 shared A. Somasundaram· 2 shared B. J. McVerry· 2 shared B. Methe· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

A. R. Cillo

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5 papers

Recent·Most cited

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

S. P. Peddireddy, S. A. Rahman, A. R. Cillo, G. M. Vijay, A. Somasundaram, C. J. Workman, W. Bain, B. J. McVerry, B. Methe, J. S. Lee, P. Ray, A. Ray, T. C. Bruno, D. A. Vignali, G. D. Kitsios, , J. Das

The paper identifies antibody responses against non-canonical and endemic coronavirus antigens as predictors of favorable outcomes in severe COVID-19.

bioRxiv · Jan 24, 2022Immunology

Bifurcated monocyte states are predictive of mortality in severe COVID-19

A. R. Cillo, A. Somasundaram, F. Shan, C. Cardello, C. J. Workman, G. D. Kitsios, A. Ruffin, S. Kunning, C. Lampenfeld, S. Onkar, S. Grebinowski, G. Deshmukh, B. Methe, C. Liu, S. Nambulli, , D. A. Vignali

The paper identifies bifurcated monocyte states in severe COVID-19 patients that predict mortality, with distinct cytokine and interferon gene modules associated with survival or death.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Microbiome-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer.

A. E. Overacre-Delgoffe, A. R. Cillo, H. J. Bumgarner, A. H. Burr, J. T. Tometich, A. Bhattacharjee, T. C. Bruno, D. A. Vignali, T. Hand

The paper shows that introducing an immunogenic commensal bacteria modifies the microbiome to enhance anti-tumor immunity in colorectal cancer by promoting tertiary lymphoid structures and T follicular helper cell activity.

bioRxiv · Jan 27, 2021 · PreprintImmunology

Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures

A. T. Ruffin, A. R. Cillo, T. Tabib, A. Liu, S. Onkar, S. Kunning, C. Lampenfeld, I. Abecassis, Z. Qi, R. Soose, U. D. Duvvuri, S. Kim, S. Oesterreich, R. Lafyatis, R. L. Ferris, , T. C. Bruno

This study identifies distinct B cell signatures and tertiary lymphoid structures in HPV+ and HPV- HNSCC, highlighting their role in antitumor immunity.

bioRxiv · May 29, 2020 · PreprintImmunology

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

L. Zhu, J. L. Narloch, S. Onkar, M. Joy, C. Luedke, A. Hall, R. Kim, K. Pogue-Geile, S. Sammons, N. Nayyar, U. Chukwueke, P. K. Brastianos, C. K. Anders, A. C. Soloff, D. A. Vignali, , A. V. Lee

The paper compares immune cell infiltration in primary and metastatic breast tumors, finding reduced immune cell abundance but increased M2-like macrophages in metastases.

bioRxiv · Jan 20, 2019Immunology