Author

T. Heskes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Lederer· 2 shared T. Dijkstra· 1 shared T. M. H. Dijkstra· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 2 mutual co-author links

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2 shared papersPharmacology & Toxicology

S. Lederer

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivJul 31, 2019

Additive Dose Response Models: Defining Synergy

S. Lederer, T. Dijkstra, T. Heskes

The paper introduces an improved method for measuring synergy in compound combinations by comparing measured responses to expected non-interactive responses using the Explicit Mean Equation.

DOI 10.3389/fphar.2019.01384

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivJul 9, 2017

Additive Dose Response Models: Explicit Formulations and the Loewe Additivity Consistency Condition

S. Lederer, T. M. H. Dijkstra, T. Heskes

The paper derives explicit and implicit null reference models based on Loewe Additivity and shows the explicit model has lower error and faster computation.

DOI 10.3389/fphar.2018.00031

statistical modelbenchmarking

𝕏 PostBluesky