S. Lederer

Imaging of plant calcium-sensor kinase conformation monitors real time calcium decoding in planta

The paper develops a FRET-based reporter to visualize calcium-dependent protein kinase conformational changes in real time, revealing isoform-specific calcium decoding in plant cells.

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

This study isolates potent SARS-CoV-2-neutralizing antibodies from COVID-19 patients as early as 8 days post-diagnosis and identifies precursor B cells in healthy individuals.

Additive Dose Response Models: Defining Synergy

The paper introduces an improved method for measuring synergy in compound combinations by comparing measured responses to expected non-interactive responses using the Explicit Mean Equation.

Additive Dose Response Models: Explicit Formulations and the Loewe Additivity Consistency Condition

The paper derives explicit and implicit null reference models based on Loewe Additivity and shows the explicit model has lower error and faster computation.