Author

T. Huseinbegovic

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Evolutionary Biology· 1

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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A. de la Paz· 1 shared C. M. Nartey· 1 shared F. Morcos· 1 shared N. Mercado· 1 shared S. Alvarez· 1 shared

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2023-2023 · peak 1/yr

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1 shared paperEvolutionary Biology

A. de la Paz

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Evolutionary BiologybioRxivMay 24, 2023

In vivo functional phenotypes from a computational epistatic model of evolution

S. Alvarez, C. M. Nartey, N. Mercado…·F. Morcos

The paper develops a computational model to evolve functional protein variants in E. coli, showing that epistatic constraints can generate active beta-lactamase variants with enhanced activity.

DOI 10.1073/pnas.2308895121

E. coliprotein sequence

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