Author

N. Mercado

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Organism:E. coli· 1 Assay:metagenomics· 1 Organism:non-human primate· 1 Research Focus:protein design· 1

Frequent Co-Authors

A. Chandrashekar· 2 shared D. H. Barouch· 2 shared J. Yu· 2 shared A. Cole· 1 shared A. Cook· 1 shared A. de la Paz· 1 shared A. Martinot· 1 shared B. Petsch· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. Chandrashekar

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3 papers

Recent·Most cited

In vivo functional phenotypes from a computational epistatic model of evolution

S. Alvarez, C. M. Nartey, N. Mercado, A. de la Paz, T. Huseinbegovic, F. Morcos

The paper develops a computational model to evolve functional protein variants in E. coli, showing that epistatic constraints can generate active beta-lactamase variants with enhanced activity.

bioRxiv · May 24, 2023Evolutionary Biology

Optimization of Non-Coding Regions Improves Protective Efficacy of an mRNA SARS-CoV-2 Vaccine in Nonhuman Primates

M. Gebre, S. Rauch, N. Roth, J. Yu, A. Chandrashekar, N. Mercado, X. He, J. Liu, K. McMahan, A. Martinot, T. Giffin, D. Hope, S. Patel, D. Sellers, O. Sanborn, , D. H. Barouch

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

bioRxiv · Aug 13, 2021 · PreprintImmunology

SARS-CoV-2 binding and neutralizing antibody levels after vaccination with Ad26.COV2.S predict durable protection in rhesus macaques

R. Roozendaal, L. Solforosi, D. Stieh, J. Serroyen, R. Straetemans, F. Wegmann, S. K. Rosendahl Huber, J. E. M. van der Lubbe, J. Hendriks, M. le Gars, L. Dekking, D. N. Czapska-Casey, N. Guimera, S. Janssen, S. Tete, , R. Zahn

This study shows that Ad26.COV2.S vaccine provides long-lasting protection in rhesus macaques, predicted by binding and neutralizing antibody levels against SARS-CoV-2.

bioRxiv · Jan 30, 2021Immunology