ImmunologybioRxivPreprint
Transient "rest" induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells
E. W. Weber, R. C. Lynn, K. R. Parker…·C. L. Mackall
This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.