Structural basis of aggregate binding by the AAA+ disaggregase ClpG
P. Katikaridis, B. Simon, T. Jenne, S. Moon, C. Lee, J. Hennig, A. Mogk
The paper determines the structure of the ClpG disaggregase's N1 domain, revealing how it recognizes and binds protein aggregates through hydrophobic interactions and Zn2+ coordination.
bioRxiv · Aug 31, 2023Biochemistry