B. Simon

CombiCTx: Screening diffusion gradients of anti-cancer drug combinations

The paper introduces CombiCTx, an assay for screening anti-cancer drug combinations by simulating drug diffusion gradients in a tumor-like environment to assess interactions and cytotoxic effects.

Evolutionary branching in multi-level selection models

This study examines evolutionary dynamics in multi-level selection models, showing that weaker individual-level selection promotes group-level diversification while stronger selection enhances group adaptation.

The Drosophila RNA binding protein Hrp48 binds a specificRNA sequence of the msl-2 mRNA 3' UTR to regulatetranslation

This paper identifies the RNA binding specificity of Hrp48, showing it binds the msl-2 mRNA 3' UTR independently of Sxl and Unr downstream of their binding sites.

The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

This study identifies ClpL from Listeria monocytogenes as a potent AAA+ disaggregase that enhances heat resistance by efficiently solubilizing protein aggregates under severe stress.

Structural basis of aggregate binding by the AAA+ disaggregase ClpG

The paper determines the structure of the ClpG disaggregase's N1 domain, revealing how it recognizes and binds protein aggregates through hydrophobic interactions and Zn2+ coordination.

Structural basis for specific RNA recognition by the alternative splicing factor RBM5

This paper investigates how RBM5's RNA-binding domains recognize specific RNA motifs to regulate alternative splicing, revealing structural and cooperative mechanisms.

Tropomyosin 1-I/C co-ordinates kinesin-1 and dynein motors during oskar mRNA transport

This study shows Tm1-I/C coordinates kinesin-1 and dynein during oskar mRNA transport by inhibiting kinesin-1 until it is needed in the oocyte.

In vitro floral development in poplar: Insights into seed trichome and trimonoecy regulation

The paper develops an in vitro flowering system in poplar to study reproductive traits like sex, seed trichomes, and trimonoecy.

Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans

The paper determines the structure of the PETISCO complex in C. elegans and elucidates its role in piRNA biogenesis and early embryogenesis.

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.

Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless

This study determines the NMR structure of MLE's dsRBD1 and dsRBD2 and shows they bind dsRNA independently, but dsRBD1 mutants do not affect roX2 binding or MLE localization.

Evolution of influenza genome diversity during infection in immunocompetent patients

This study tracks influenza virus diversity over time in immunocompetent patients, finding higher diversity in late-stage mild cases and specific segment differences across clinical groups.

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.