Author

A. Mogk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Organism:bacteria (other)· 3 Assay:protein structure· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

B. Simon· 2 shared J. Hennig· 2 shared P. Katikaridis· 2 shared B. Bukau· 1 shared C. A. Sandhof· 1 shared C. Lee· 1 shared C. Nussbaum-Krammer· 1 shared D. Flemming· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

B. Simon

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Author profile →

4 papers

Recent·Most cited

The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

V. Bohl, N. M. Hollmann, T. Melzer, P. Katikaridis, L. Meins, B. Simon, D. Flemming, I. Sinning, J. Hennig, A. Mogk

This study identifies ClpL from Listeria monocytogenes as a potent AAA+ disaggregase that enhances heat resistance by efficiently solubilizing protein aggregates under severe stress.

bioRxiv · Oct 8, 2023 · PreprintBiochemistry

Structural basis of aggregate binding by the AAA+ disaggregase ClpG

P. Katikaridis, B. Simon, T. Jenne, S. Moon, C. Lee, J. Hennig, A. Mogk

The paper determines the structure of the ClpG disaggregase's N1 domain, revealing how it recognizes and binds protein aggregates through hydrophobic interactions and Zn2+ coordination.

bioRxiv · Aug 31, 2023Biochemistry

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

J. Tittelmeier, C. A. Sandhof, H. M. Ries, S. Druffel-Augustin, A. Mogk, B. Bukau, C. Nussbaum-Krammer

This study shows that HSP110-dependent HSP70 disaggregation machinery both maintains proteostasis and promotes prion-like propagation of amyloidogenic proteins in metazoa.

bioRxiv · Oct 9, 2019Cell Biology

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

A. Mogk

The paper shows how coiled-coil domains regulate AAA+ chaperone activity by forming head-to-head assemblies, controlling their activation and repression.

bioRxiv · Jul 20, 2017Biochemistry