BiophysicsbioRxiv
Structural basis for substrate selection by the SARS-CoV-2 replicase
B. F. Malone, J. K. Perry, P. D. B. Olinares…·S. A. Darst
This study uses cryo-EM to reveal how the SARS-CoV-2 RTC discriminates between natural NTPs and the antiviral remdesivir triphosphate, providing insights for antiviral design.
DOI 10.1038/s41586-022-05664-3