Author

H. Ng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

A. Osunsade· 1 shared B. F. Malone· 1 shared B. T. Chait· 1 shared E. A. Campbell· 1 shared E. T. Eng· 1 shared E. Y. D. Chua· 1 shared J. Chang· 1 shared J. Chen· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

A. Osunsade

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2 papers

Recent·Most cited

Structural basis for substrate selection by the SARS-CoV-2 replicase

B. F. Malone, J. K. Perry, P. D. B. Olinares, J. Chen, T. K. Appleby, J. Y. Feng, J. P. Bilello, H. Ng, J. Sotiris, M. Ebrahim, E. Y. D. Chua, J. H. Mendez, E. T. Eng, R. Landick, B. T. Chait, , S. A. Darst

This study uses cryo-EM to reveal how the SARS-CoV-2 RTC discriminates between natural NTPs and the antiviral remdesivir triphosphate, providing insights for antiviral design.

bioRxiv · May 20, 2022Biophysics

Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA

T. Nguyen, S. Li, J. Chang, J. Watters, H. Ng, A. Osunsade, Y. David, S. Liu

This study shows that Sox2 forms DNA condensates that exert mechanical forces up to 7 pN, but chromatin nucleosomes reduce this force by sequestering Sox2.

bioRxiv · Feb 2, 2022Biophysics