Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15
J. Davidson, R. Jain, T. Kizzar, G. Geoghegan, D. J. Nesbitt, A. T. Cavanagh, A. Abe, A. Hunger, X. Chao, I. James, D. Baldwin, R. Verma, K. L. Schueler, V. Hinkoka-Galcheva, S. Michorowska, , J. Simcox
The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.
bioRxiv · Nov 3, 2023Biochemistry