Author

I. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. Simcox· 2 shared A. Abe· 1 shared A. Barlier· 1 shared A. Chopra· 1 shared A. Hunger· 1 shared A. J. Keeley· 1 shared A. Sette· 1 shared A. T. Cavanagh· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersPhysiology

J. Simcox

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

M. E. Trautman, C. L. Green, M. R. MacArthur, K. Chaiyakul, Y. H. Alam, C.-Y. Yeh, R. Babygirija, I. James, M. Gilpin, E. Zelenovskiy, M. Green, R. N. Marshall, M. M. Sonsalla, V. Flores, J. Simcox, , D. Lamming

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Molecular Metabolism · Nov 1, 2025Peer-reviewedPhysiology

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

D. Aldea, N. Macagno, E. Marechal, M. Moreno, P. Romanet, M. Pertuit, J. Garcia, N. Degardin, S. Mallet, I. James, G. Captier, A. Barlier, H. C. Etchevers

The paper uses weighted whole-genome methylation analysis to distinguish between congenital and acquired melanocytic nevi.

bioRxiv · Jun 11, 2024Cancer Biology

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

J. Davidson, R. Jain, T. Kizzar, G. Geoghegan, D. J. Nesbitt, A. T. Cavanagh, A. Abe, A. Hunger, X. Chao, I. James, D. Baldwin, R. Verma, K. L. Schueler, V. Hinkoka-Galcheva, S. Michorowska, , J. Simcox

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

bioRxiv · Nov 3, 2023Biochemistry

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

S. Leary, S. Gaudieri, M. D. Parker, A. Chopra, I. James, S. Pakala, E. Alves, M. John, B. B. Lindsey, A. J. Keeley, S. L. Rowland-Jones, M. Swanson, D. A. Ostrov, J. L. Bubenik, S. Das, , S. Mallal

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

bioRxiv · Apr 10, 2020 · PreprintMicrobiology