J. Simcox

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15

The paper identifies TFEB regulation of BMP lipid catabolism via Pla2g15, showing increased BMP lipids in Pla2g15 knockout mice and cold intolerance upon TFEB knockdown.

Ormdl3 regulation of specific ceramides is dispensable for β-cell function and glucose homeostasis under obesogenic conditions

This study shows that loss of Ormdl3 in β-cells does not affect glucose homeostasis on standard diet but increases specific ceramide levels under high fat diet.

Late-life isoleucine restriction promotes physiological and molecular signatures of healthy aging

This study shows that reducing amino acids or isoleucine in the diet of aged mice improves metabolic health, reduces frailty, and slows aging markers.

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

This study shows that reducing dietary isoleucine improves metabolic health, reduces frailty, and extends lifespan in genetically diverse mice.

Systematic assessment of lipid profiles for the discovery of tissue contributors to the circulating lipid pool in cold exposure

The paper uses lipidomics and computational analysis to identify tissues contributing to plasma lipid pools during cold exposure, finding the kidney and intestine as novel contributors to acylcarnitines and BAT and kidney as regulators of ceramides.

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.