Author

T. Kouba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:virus· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Busch· 2 shared D. Vogel· 2 shared E. R. J. Quemin· 2 shared K. Gruenewald· 2 shared M. Rosenthal· 2 shared S. Cusack· 2 shared S. Guenther· 2 shared S. R. Thorkelsson· 2 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBiochemistry

C. Busch

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2 papers

Recent·Most cited

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

T. Kouba, D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, H. M. Williams, M. Milewski, C. Busch, S. Guenther, K. Gruenewald, M. Rosenthal, S. Cusack

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

bioRxiv · Jun 24, 2021Biochemistry

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, K. Meier, T. Kouba, N. Gogrefe, C. Busch, S. Reindl, S. Guenther, S. Cusack, K. Gruenewald, M. Rosenthal

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.

bioRxiv · Mar 2, 2020Biochemistry