S. Cusack

Structural snapshots of phenuivirus cap-snatching and transcription

The paper presents cryo-EM structures of SFTSV L protein during cap-snatching and transcription, revealing conformational changes and RNA binding mechanisms.

Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family

This study characterizes the structure and function of the minimal orthomyxovirus-like polymerase from Tilapia Lake Virus, revealing its active domains and inactive features.

Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex

The paper reveals how different effectors compete for binding to the CBC-ARS2 complex, influencing RNA fate through structural and biochemical analysis.

Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface

The paper determines the structure of the RIP2K-XIAP BIR2 complex, revealing its dimeric conformation and molecular mechanisms of interaction.

Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein

This study presents cryo-EM structures of the SFTSV L protein during genome replication, revealing RNA binding and elongation mechanisms.

Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex

The paper presents structural analyses of Red1's interactions with RNA regulators and shows their role in meiotic mRNA degradation and complex dimerization.

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription

This study uses cryo-EM to reveal the structural dynamics of La Crosse virus polymerase, elucidating mechanisms of replication and transcription in Peribunyaviridae.

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.

Molecular Basis of Host-Adaptation Interactions between Influenza Virus Polymerase PB2 Subunit and ANP32A

This study identifies molecular interactions between influenza PB2 subunit variants and ANP32A that explain host adaptation and species-specific restriction of viral replication.

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.