Author

C. Busch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Pharmacology & Toxicology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Organism:virus· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. Vogel· 4 shared M. Rosenthal· 4 shared S. Cusack· 4 shared S. R. Thorkelsson· 4 shared E. R. J. Quemin· 3 shared H. M. Williams· 3 shared M. Milewski· 3 shared K. Gruenewald· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersBiochemistry

D. Vogel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural snapshots of phenuivirus cap-snatching and transcription

H. M. Williams, S. R. Thorkelsson, D. Vogel, C. Busch, M. Milewski, S. Cusack, K. Grunewald, E. R. J. Quemin, M. Rosenthal

The paper presents cryo-EM structures of SFTSV L protein during cap-snatching and transcription, revealing conformational changes and RNA binding mechanisms.

bioRxiv · Nov 29, 2023Biochemistry

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

D. Kehr, J. Ritterhoff, M. Glaser, L. Jarosch, R. Salazar, K. Spaich, K. Varadi, J. Birkenstock, M. Egger, E. Gao, W. J. Koch, H. A. Katus, N. Frey, A. Jungmann, C. Busch, , P. Most

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

bioRxiv · Mar 4, 2023Pharmacology & Toxicology

Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein

H. M. Williams, S. R. Thorkelsson, D. Vogel, M. Milewski, C. Busch, S. Cusack, K. Grunewald, E. Quemin, M. Rosenthal

This study presents cryo-EM structures of the SFTSV L protein during genome replication, revealing RNA binding and elongation mechanisms.

bioRxiv · Aug 25, 2022Biochemistry

Public exams decrease anxiety and facilitate deeper conceptual thinking

B. Wiggins, L. Lily, C. Busch, M. Landys, J. G. Shlichta, T. Shi, T. Ngwenyama

This study evaluates public exams as an assessment method, finding they reduce anxiety and promote deeper conceptual thinking without worsening outcome disparities.

bioRxiv · Apr 15, 2022 · PreprintScientific Communication & Education

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

T. Kouba, D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, H. M. Williams, M. Milewski, C. Busch, S. Guenther, K. Gruenewald, M. Rosenthal, S. Cusack

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

bioRxiv · Jun 24, 2021Biochemistry

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, K. Meier, T. Kouba, N. Gogrefe, C. Busch, S. Reindl, S. Guenther, S. Cusack, K. Gruenewald, M. Rosenthal

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.

bioRxiv · Mar 2, 2020Biochemistry