Author

S. R. Thorkelsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:virus· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Busch· 3 shared D. Vogel· 3 shared M. Rosenthal· 3 shared S. Cusack· 3 shared E. R. J. Quemin· 2 shared H. M. Williams· 2 shared K. Gruenewald· 2 shared M. Milewski· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

C. Busch

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3 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedJan 18, 2023

Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein

H. M. Williams, S. R. Thorkelsson, D. Vogel…·M. Rosenthal

This study presents cryo-EM structures of the SFTSV L protein during genome replication, revealing RNA binding and elongation mechanisms.

DOI 10.1093/nar/gkac1249

𝕏 PostBluesky

BiochemistrybioRxivJun 24, 2021

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

T. Kouba, D. Vogel, S. R. Thorkelsson…·S. Cusack

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

DOI 10.1038/s41467-021-27305-5

𝕏 PostBluesky

BiochemistrybioRxivMar 2, 2020

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

D. Vogel, S. R. Thorkelsson, E. R. J. Quemin…·M. Rosenthal

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.

DOI 10.1093/nar/gkaa253

virusstructural biology

𝕏 PostBluesky