Author

T. L. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. Davenport· 2 shared R. E. Kuc· 2 shared S. Sinha· 2 shared A. J. Butler· 1 shared A. M. Moon· 1 shared A. W. Lohse· 1 shared C. J. E. Watson· 1 shared C. Roan· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

A. P. Davenport

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Bordetella Spp. Utilize T3SS To Promote Secretion of IL1RA Leading to Long-Term Per-sistent Infections

T. L. Williams, C. Roan, N. J. First, S. Johnson, M. C. Gestal

This study shows Bordetella spp. use T3SS to secrete IL1RA, promoting persistent infections and suggesting IL1RA as a therapeutic target for whooping cough.

bioRxiv · Sep 26, 2022 · PreprintMicrobiology

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

T. Brevini, M. Maes, G. J. Webb, W. T. H. Gelson, S. Forrest, P. Mlcochova, S. Dillon, S. Varankar, M. Darvish-Damavandi, V. L. Mulcahy, R. E. Kuc, T. L. Williams, V. Galanakis, M. Vila-Gonzalez, O. C. Tysoe, , F. Sampaziotis

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection

T. L. Williams, M. T. Colzani, R. G. Macrae, E. L. Robinson, S. Bloor, E. J. Greenwood, J. R. Zhan, G. Strachan, R. E. Kuc, D. Nyimanu, J. J. Maguire, P. J. Lehner, S. Sinha, A. P. Davenport

The paper identifies benztropine and DX600 as inhibitors of SARS-CoV-2 infection using a screening platform with human embryonic stem cell-derived cardiomyocytes.

bioRxiv · Jan 22, 2021 · PreprintPharmacology & Toxicology