Author

S. Forrest

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 3 Organism:bacteria (other)· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

G. Dougan· 3 shared S. Baker· 3 shared M. Maes· 2 shared S. Sridhar· 2 shared A. Andrews· 1 shared A. Buck· 1 shared A. J. Butler· 1 shared A. J. Fraser· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

G. Dougan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase producing Enterobacterales

F. E. Graf, R. N. Goodman, S. Gallichan, S. Forrest, E. Picton-Barlow, A. J. Fraser, M.-D. Phan, M. Mphasa, A. T. Hubbard, P. Musicha, M. A. Schembri, A. P. Roberts, T. Edwards, J. M. Lewis, N. A. Feasey

The paper investigates the re-emerging chloramphenicol susceptibility in ESBL-producing Enterobacterales by analyzing genotype-phenotype discordance and molecular mechanisms.

bioRxiv · Nov 16, 2023Microbiology

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

T. Brevini, M. Maes, G. J. Webb, W. T. H. Gelson, S. Forrest, P. Mlcochova, S. Dillon, S. Varankar, M. Darvish-Damavandi, V. L. Mulcahy, R. E. Kuc, T. L. Williams, V. Galanakis, M. Vila-Gonzalez, O. C. Tysoe, , F. Sampaziotis

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Spatially distributed infection increases viral load in a computational model of SARS-CoV-2 lung infection

M. E. Moses, S. Hofmeyr, J. L. Cannon, A. Andrews, R. Gridley, M. Hinga, K. Leyba, A. Pribisova, V. Surjadidjaja, H. Tasnim, S. Forrest

This paper develops a computational model of SARS-CoV-2 lung infection that shows spatially distributed infections increase viral load and demonstrates how T cell response timing affects viral persistence.

bioRxiv · May 19, 2021Immunology

Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of Salmonella Typhimurium

S. Sridhar, S. Forrest, D. Pickard, C. Cormie, E. Lees, N. Thomson, G. Dougan, S. Baker

This study shows that inhibitory concentrations of ciprofloxacin induce adaptive responses in Salmonella Typhimurium that enhance intracellular survival and replication.

bioRxiv · May 6, 2021Microbiology

High-content imaging to phenotype antimicrobial effects on individual bacteria at scale

S. Sridhar, S. Forrest, B. Warne, M. Maes, S. Baker, G. Dougan, J. Bartholdson Scott

This paper develops a high-throughput high-content imaging method to phenotype bacterial responses to antimicrobials, revealing morphological differences between susceptible and resistant isolates.

bioRxiv · Jan 11, 2021Microbiology

Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

M. A. Duque-Correa, F. Schreiber, F. H. Rodgers, D. Goulding, S. Forrest, R. White, A. Buck, R. K. Grencis, M. Berriman

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

bioRxiv · May 11, 2020Immunology