T. Michaels

The Alzheimer's Amyloid beta peptide forms biomolecular condensates that trigger amyloid aggregation

This paper shows that Alzheimer's amyloid-beta peptide forms biomolecular condensates on lipid bilayers, accelerating amyloid aggregation and revealing a new early step in the disease mechanism.

Tie-lines reveal interactions driving heteromolecular condensate formation

The paper develops a method to determine tie-line gradients in ternary LLPS systems using dilute phase concentration measurements, revealing interaction types and compositions in biomolecular condensates.