J. Wei

IL-3-driven T cell-basophil crosstalk enhances anti-tumor immunity

This study shows that IL-3 enhances anti-tumor immunity by promoting CTL-basophil interactions, improving CTL activity and tumor suppression.

Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

The Alzheimer's Amyloid beta peptide forms biomolecular condensates that trigger amyloid aggregation

This paper shows that Alzheimer's amyloid-beta peptide forms biomolecular condensates on lipid bilayers, accelerating amyloid aggregation and revealing a new early step in the disease mechanism.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Inhibition of KLK8 promotes pulmonary endothelial repair by restoring VE-cadherin/Akt/FOXM1 pathway

This study shows that inhibiting KLK8 restores the VE-cadherin/Akt/FOXM1 pathway, promoting endothelial repair and reducing sepsis-induced lung injury and mortality.

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53

This study shows that SARS-CoV-2 variants differ in syncytia formation, which affects host chromatin accessibility, cellular senescence, and inflammation via TP53.

Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition.

This study identifies Gli3's role in regulating ossification pathways in zebrafish pectoral girdles, revealing developmental trade-offs that may explain the evolution of tetrapod-like structures.

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

This study shows metformin improves bone healing in diabetic mice by enhancing BMSC differentiation and chondrogenesis.

Urine proteomic characterization of active and recovered COVID-19 patients

This study characterizes urine proteomic changes in active and recovered COVID-19 patients, identifying persistent immune and metabolic alterations and potential biomarkers.

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

Exosomes derived from BMSCs with miR-124-3p inhibitor protects against LPS-induced endometritis through regulation of DUSP6, p-p65 and p-ERK

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

The paper measures protein synthesis rates in lymphocytes and finds that their in vivo elongation rates increase with activation, despite a high protein-to-ribosome ratio suggesting insufficient capacity for rapid division.

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

Kinase-independent activity of DYRK1A promotes viral entry of highly pathogenic human coronaviruses

This study shows DYRK1A promotes viral entry of SARS-CoV, SARS-CoV-2, and MERS-CoV by regulating ACE2 and DPP4 transcription without its kinase activity.

Enhanced Single RNA Imaging Reveals Dynamic Gene Expression in Live Animals

This paper introduces a method to image endogenous mRNAs in live animals with high temporal resolution and applies it to study gene expression dynamics in C. elegans epidermis.

Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence

This study shows that glucocorticoid receptor activation during human microglial differentiation causes genomic instability and senescence, linking early-life stress to neurodevelopmental disorders.

Generalisation of early learned tutor song preferences in female zebra finches (Taeniopygia guttata)

This study investigates how female zebra finches generalize early learned song preferences to similar songs, finding that preference correlates with syllable overlap with the original tutor song.

The mechanism underlying redundant functions of the YTHDF proteins

This study investigates the redundant functions of YTHDF proteins, showing that YTHDF1 and YTHDF2 have distinct roles in RNA decay and condensate formation, and that RNA stabilization after YTHDF depletion is m6A-independent.

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

Augmented glucose dependency of autoreactive B cells provides a treatment target forlupus

This study identifies glycolysis-dependent autoreactive B cells as key mediators of lupus and shows that targeting them with 2DG or BCMA-specific CAR T-cells improves disease outcomes.

Oral administration of bacterial Beta cell expansion factor A (BefA) alleviates diabetes in mice with Type 1 and Type 2 diabetes

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

High-throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain

The paper develops a high-throughput assay for screening inhibitors of the SARS-CoV-2 Mac1 macrodomain and identifies dasatinib and dihydralazine as inhibitors with selectivity over human MacroD2.

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

The paper develops a deep learning model to predict CRISPR-Cas13d guide RNA efficiency and identifies novel orthologs with improved specificity and reduced toxicity for RNA targeting.

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography

This paper introduces a high-accuracy and high-efficiency digital volume correlation method to analyze in-vivo optic nerve head biomechanics from OCT data, showing improved performance over conventional methods.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.