K. Garai

The Alzheimer's Amyloid beta peptide forms biomolecular condensates that trigger amyloid aggregation

This paper shows that Alzheimer's amyloid-beta peptide forms biomolecular condensates on lipid bilayers, accelerating amyloid aggregation and revealing a new early step in the disease mechanism.

Apolipoprotein-E transforms intracellular Amyloid-β oligomers to a more toxic state

The paper shows ApoE modifies Aβ oligomers to a more toxic form, detectable in live cells, and presents a potential assay for AD drug discovery.

Structural Features and Oligomeric Nature of Human Podocin Domain

This study investigates the oligomeric structure of a truncated podocin domain, showing it primarily forms a 16mer with significant secondary structure and moderate tertiary packing.

Hsp70 inhibits aggregation of Islet amyloid polypeptide by binding to the heterogeneous prenucleation oligomers

This study shows Hsp70 inhibits IAPP aggregation by binding to oligomers, not monomers, preventing aberrant aggregation while preserving IDP function.

Apolipoprotein E interacts with amyloid-β oligomers via positively cooperative multivalent binding

This study investigates how apoE interacts with Aβ oligomers through cooperative multivalent binding, showing that full-length apoE has higher binding affinity than its fragments.

A fluorescence correlation spectrometer for measurements in cuvettes

This paper develops a fluorescence correlation spectrometer for single molecule measurements in cuvettes, achieving high counts per molecule and enabling protein unfolding studies with automatic titrators.