K. Ishihara

Thymically imprinted differential responsivity of naive CD4 T cells to IL2 results in a heterogeneity of both Treg induction and subsequent effector functioning

This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.

The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after open mitosis in mammalian cells

This study examines the ultrastructure of ER-NE junctions in mammalian cells, revealing a constricted hourglass shape in interphase cells that emerges during telophase.

Topological morphogenesis of neuroepithelial organoids

This study shows that trans and cis epithelial fusion regulate tissue topology and shape in neuroepithelial organoids, and identifies a pharmacologically accessible pathway to control organoid topology.

Spatial Variation of Microtubule Depolymerization in Large Asters Suggests Regulation by MAP Depletion

The paper measures microtubule depolymerization rates in Xenopus egg extract asters and finds higher rates in the interior compared to the periphery, suggesting regulation by MAP depletion.

Spindle scaling is governed by cell boundary regulation of microtubule nucleation

The paper shows that microtubule nucleation, not polymerization, governs spindle scaling across all cell sizes by regulating nucleation inhibitor partitioning to the cell membrane.

Force generation by protein-DNA co-condensation

The paper shows DNA condensation mediated by transcription factors generates forces that bring distant DNA regions together, suggesting a physical mechanism for chromatin organization.

Traveling fronts in self-replicating persistent random walks with multiple internal states

The paper analyzes traveling fronts in self-replicating persistent random walks with multiple internal states, deriving expansion velocity formulas and showing discontinuous transitions in propagation.

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

Physical basis of large microtubule aster growth

This study develops a biophysical model of microtubule aster growth that predicts traveling waves and explosive transitions, confirmed by experiments in frog egg extract.