T. Mitra

Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centres

This study uses simulations to show how T follicular regulatory cells (Tfrs) suppress self-reactive B cells in germinal centers by inducing apoptosis and regulating differentiation, with outcomes dependent on Tfr location and number.

Amount of antigen, T follicular helper cells and quality of seeder cells shape the diversity of germinal center B cells

This study uses an agent-based model to show that antigen availability, T follicular helper cells, and high-affinity founder cells influence germinal center B cell diversity and affinity maturation.

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

Emergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scales

This study shows that the MAPK signaling cascade exhibits persistent adaptive responses and memory-like behavior due to diverse relaxation time-scales, even without explicit feedback.