Author

A. Leithner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Organism:E. coli· 1 Assay:flow cytometry· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

M. Sixt· 3 shared R. Hauschild· 2 shared A. Nixon· 1 shared C. C. Guet· 1 shared D. Klenerman· 1 shared D. Wyatt· 1 shared D. Young· 1 shared E. Jenkins· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

M. Sixt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency

A. Leithner, O. Staufer, T. Mitra, F. Liberta, S. Valvo, M. Kutuzov, H. Dada, J. Spaeth, S. Zhou, F. Schiele, S. Reindl, H. Nar, S. Hoerer, M. Crames, S. Comeau, , M. L. Dustin

The paper evaluates TcE formats to determine how contact distance and flexibility affect their potency in forming immunological synapses.

bioRxiv · Jun 15, 2022Immunology

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14

K. Tomasek, A. Leithner, I. Glatzova, M. S. Lukesch, C. C. Guet, M. Sixt

This study identifies CD14 as a binding partner of FimH in uropathogenic E. coli, revealing a mechanism by which bacteria evade the immune response and suggesting a therapeutic target for persistent infections.

bioRxiv · Oct 18, 2021Immunology

Mechanosensitivity of amoeboid cells crawling in 3D

F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl, A. Leithner, J. Merrin, V. Zheden, W. A. Kaufmann, R. Hauschild, M. Sixt

This study shows how amoeboid cells use WASp-driven actin spikes to push against mechanical loads in 3D environments, enabling efficient migration through dense tissues.

bioRxiv · May 11, 2021Cell Biology

Dendritic cell actin dynamics controls T cell priming efficiency at the immunological synapse

A. Leithner, L. M. Altenburger, R. Hauschild, F. Assen, K. Rottner, T. E. B. Stradal, J. V. Stein, M. Sixt

This study shows that dendritic cell actin dynamics, regulated by the WAVE complex, influence T cell priming efficiency at the immunological synapse by modulating synaptic structure and adhesion.

bioRxiv · Jun 13, 2020Cell Biology