BiochemistrybioRxivPreprint
Covalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators
Q. Shao, T. N. Duong, I. Park, D. K. Nomura
This study identifies a covalent ligand, EN171, that enhances 14-3-3 interactions with transcription factors like ER, YAP, and TAZ, inhibiting their activity and demonstrating its use in heterobifunctional molecules to sequester nuclear substrates.
DOI 10.1101/2023.11.06.565850