Author

I. Park

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 2 Microbiology· 2 Cancer Biology· 1 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:metagenomics· 2 Assay:proteomics· 2

Frequent Co-Authors

H.-W. Rhee· 2 shared J. Kim· 2 shared J. M. Suh· 2 shared J.-S. Kim· 2 shared K.-e. Kim· 2 shared M.-G. Kang· 2 shared R. Bashir· 2 shared S. Kim· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

H.-W. Rhee

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Covalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators

Q. Shao, T. N. Duong, I. Park, D. K. Nomura

This study identifies a covalent ligand, EN171, that enhances 14-3-3 interactions with transcription factors like ER, YAP, and TAZ, inhibiting their activity and demonstrating its use in heterobifunctional molecules to sequester nuclear substrates.

bioRxiv · Nov 6, 2023 · PreprintBiochemistry

Enhanced Omicron subvariant cross-neutralization efficacy of a monovalent SARS-CoV-2 BA.4/5 mRNA vaccine encoding a noncleaved, nonfusogenic spike antigen

H. Y. Seo, H. Jung, H. Woo, H.-G. Jung, Y. Bak, S.-Y. Lee, Y.-M. Son, G. Yoon, Y.-M. Son, S.-Y. Hwang, I. Park, J.-S. Shin, J.-W. Oh

This study develops a modified SARS-CoV-2 spike antigen that enhances cross-neutralization against Omicron subvariants, despite reduced neutralizing potency.

bioRxiv · Sep 10, 2023 · PreprintImmunology

Highly localized chemical sampling at sub-second temporal resolution enabled with a silicon nanodialysis platform at exceedingly slow flows.

I. Park, S. Kim, C. Brenden, W. Shi, H. Iyer, R. Bashir, Y. Vlasov

This paper introduces a silicon nanodialysis platform with sub-second temporal and 100μm spatial resolution, achieving 100-1000x better performance than traditional microdialysis.

bioRxiv · Sep 8, 2023 · PreprintBioengineering

Phenologically-informed species distribution models (SDMs) forecast less species loss and turnover versus standard SDMs

S. Peng, T. R. Parada, S. Mazer, S. Record, I. Park, A. M. Ellison, C. C. Davis

The paper develops phenology-informed species distribution models that predict lower species loss and turnover under climate change compared to standard models.

bioRxiv · Jul 5, 2023 · PreprintEcology

Staphylococcus aureus does not synthesize arginine from proline under physiological conditions

T. Bae, B. Jeong, M. A. Shah, E. Roh, K. K. Kim, I. Park

This study shows that Staphylococcus aureus cannot synthesize arginine from proline under physiological conditions due to low P5C concentrations, not CCR repression.

bioRxiv · Jan 12, 2022Microbiology

In vivo mitochondrial matrix proteome profiling reveals RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase

I. Park, K.-e. Kim, J. Kim, S. Bae, M. Jung, J. Choi, C. Kwak, M.-G. Kang, C.-M. Yoo, J. Y. Mun, K.-H. Liu, J.-S. Kim, J. M. Suh, H.-W. Rhee

The paper uses a transgenic mouse model to profile mitochondrial matrix proteomes and identifies RTN4IP1/OPA10 as an antioxidant NADPH oxidoreductase involved in CoQ biosynthesis and mitochondrial function.

bioRxiv · Oct 14, 2021Cell Biology

Analysis of the blood microbiome in a porcine model of fecal-induced peritonitis

H. Hyun, M. S. Lee, I. Park, H. S. Ko, S. Yun, D.-H. Jang, S. Kim, H. Kim, J. H. Kang, J. H. Lee, T. Kwon

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

bioRxiv · Feb 18, 2021Microbiology

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

K.-e. Kim, I. Park, J. Kim, M.-G. Kang, W. G. Choi, H. Shin, J.-S. Kim, H.-W. Rhee, J. M. Suh

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.

bioRxiv · Sep 21, 2020Biochemistry

Computationally assisted design and selection of maneuverable biological walking machines

J. Wang, J. Park, X. Zhang, I. Park, E. A. Kilicarslan, Y. Kim, R. Bashir, M. Gazzola

This paper presents a computationally designed dual-ring biobot that demonstrates robust forward motion and rotational steering through differential electrical stimulation.

bioRxiv · Sep 1, 2020Bioengineering

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

Z. Jagani, G. Chenail, K. Xiang, G. Bushold, H.-E. C. Bhang, A. Li, G. Elliott, J. Zhu, A. Vattay, T. Gilbert, A. Bric, R. Kikkawa, V. Dubost, R. Terranova, J. Cantwell, , Haas

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.

bioRxiv · Oct 22, 2019 · PreprintCancer Biology