Nanoscale organization of the endogenous ASC speck
I. M. Glueck, G. P. Mathias, S. Strauss, T. S. Ebert, C. Stafford, G. Agam, S. Manley, V. Hornung, R. Jungmann, C. Sieben, D. C. Lamb
This study uses super-resolution microscopy to analyze the nanoscale structure of endogenous ASC specks during NLRP3 inflammasome activation, revealing a dense core with extending filaments and changes in density during formation.
bioRxiv · Sep 17, 2021Immunology