S. Strauss

A deep learning-based toolkit for 3D nuclei segmentation and quantitative analysis in cellular and tissue context

The paper introduces computational tools for 3D nuclei segmentation and analysis, showing variations in nuclear-to-cell volume ratios across tissues.

Structure and regulation of GSDMD pores at the plasma membrane of pyroptotic cells

The paper visualizes GSDMD nanostructures at the plasma membrane of pyroptotic cells and identifies PI(3,4,5)P3 as a regulator of pore formation.

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

Cell growth rates coordinate across the width of the leaf to remain flat

The paper analyzes cell growth dynamics in Arabidopsis leaves to show that coordinated growth across the leaf blade is necessary for maintaining flatness, and that the jaw-D mutant disrupts this coordination.

Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice

This study shows that exposure to BA.4/BA.5 spike glycoprotein enhances neutralizing antibody breadth against Omicron variants in vaccinated humans and mice.

DNA-PAINT single-particle tracking (DNA-PAINT-SPT) enables extended single-molecule studies of membrane protein interactions

This paper introduces dual-colour DNA-PAINT-SPT for live cell imaging, enabling tracking of membrane protein interactions and dimerisation with improved performance over single-dye SPT.

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.

This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.

The annotation and analysis of complex 3D plant organs using 3DCoordX

The paper develops 3DCoordX, a tool for spatially annotating cells in 3D plant organs, revealing new insights into growth patterns across species.

Simultaneous multicolor DNA-PAINT without sequential fluid exchange using spectral demixing

This paper introduces a method for simultaneous multicolor DNA-PAINT imaging without fluid exchange, achieving high localization precision and multicolor registration.

Population-specific patterns of toxin sequestration in monarch butterflies from around the world

This study examines genetic variation in toxin sequestration in monarch butterflies across populations and host species, finding reduced sequestration in some populations under different ecological conditions.

Nanoscale organization of the endogenous ASC speck

This study uses super-resolution microscopy to analyze the nanoscale structure of endogenous ASC specks during NLRP3 inflammasome activation, revealing a dense core with extending filaments and changes in density during formation.

Root meristem shaping via brassinosteroid-controlled cell geometry

This study shows brassinosteroid signaling modulates cell geometry and growth anisotropy in root meristems, shaping root form without affecting cell volume.

Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

The paper investigates how rotavirus transcripts are recruited into viroplasms, showing that RNA enrichment depends on conserved terminal regions and varies among transcripts.

A molecular framework for control of oriented cell division in the Arabidopsis embryo

This study identifies auxin's role in controlling division plane orientation in Arabidopsis embryos through cytoskeleton remodeling and cell geometry.

Rotavirus Replication Factories Are Complex Ribonucleoprotein Condensates

This study shows rotavirus replication factories are RNA-protein condensates formed by phase separation, with unique features that could be targeted for antiviral therapies.

A digital 3D reference atlas reveals cellular growth patterns shaping the Arabidopsis ovule

The paper creates a 3D digital atlas of Arabidopsis ovule development, revealing cellular growth patterns and new functions in morphogenesis.

Direct Supercritical Angle Localization Microscopy for Nanometer 3D Superresolution

This paper introduces SALM, a 3D superresolution technique that improves z-resolution by four times using direct splitting of supercritical and undercritical emission.

Timing of organ initiation is crucial for robust organ size

The paper shows that DRMY1 regulates sepal size in Arabidopsis by controlling organ initiation timing and growth.

Circumvention of common labeling artifacts using secondary nanobodies

This paper demonstrates that monovalent nanobodies improve imaging accuracy and reduce artifacts compared to traditional secondary antibodies in super-resolution microscopy.

When rarity has costs: coexistence under positive frequency-dependence and environmental stochasticity

This paper analyzes how positive frequency-dependence and environmental stochasticity affect species coexistence through mathematical models.