Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues
G. L. Pearson, E. M. Walker, N. Lawlor, A. Lietzke, V. Sidarala, J. Zhu, T. Stromer, E. C. Reck, A. M. Stendahl, J. Li, E. Levi-D'Ancona, M. B. Pasmooij, D. L. Hubers, A. Renberg, K. Mohamed, , S. A. Soleimanpour
This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.
bioRxiv · Aug 2, 2022 · PreprintCell Biology