Author

T. W. Lee

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Cancer Biology· 1

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

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F. W. Hunter· 1 shared S. M. Jamieson· 1 shared W. R. Wilson· 1 shared

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2021-2021 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperCancer Biology

F. W. Hunter

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintNov 28, 2021

Random clonal expansion as a limiting factor in transplantable in vivo CRISPR/Cas9 screens

T. W. Lee, F. W. Hunter, W. R. Wilson, S. M. Jamieson

This study develops a transplantable in vivo CRISPR/Cas9 screen model for HNSCC, showing that gRNA representation declines due to clonal expansion, and identifies parameters to optimize screen success.

DOI 10.1101/2021.11.28.469740

mouseCRISPR screen

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