Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation
E. W. Morgan, F. Dong, A. Annalora, I. A. Murray, T. Wolfe, R. Erickson, K. Gowda, S. G. Amin, K. S. Petersen, P. M. Kris-Etherton, C. Marcus, S. T. Walk, A. D. Patterson, G. H. Perdew
This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.
bioRxiv · Jan 26, 2023Biochemistry