G. H. Perdew

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.