Complex chemical signals dictate Ah receptor activation through the gut-lung axis
F. Dong, I. A. Murray, A. Annalora, D. Coslo, D. Desai, K. Gowda, J. Yang, D. Wang, I. Koo, F. Hao, S. G. Amin, A. D. Patterson, C. Marcus, G. H. Perdew
The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.
bioRxiv · Feb 22, 2023Biochemistry