K. Gowda

A new efficacious Mcl-1 inhibitor maximizes bortezomib and venetoclax responsiveness in resistant multiple myeloma cells

This paper identifies KS18, a Mcl-1 inhibitor, as a potential treatment for multiple myeloma, showing it enhances apoptosis and overcomes resistance to bortezomib and venetoclax in resistant cells and mouse models.

Global patterns in gene content of soil microbiomes emerge from microbial interactions

The paper shows that environmental filtering alone cannot explain global patterns in soil microbiome gene content, as ecological interactions between genotypes drive observed associations with pH.

Learning the functional landscape of microbial communities

The paper introduces community-function landscapes to predict microbial community functions from strain presence/absence, showing they can be accurately trained with limited data and are broadly applicable.

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.

Genomic structure predicts metabolite dynamics in microbial communities

The paper shows that genomic structure can predict metabolite dynamics in microbial communities using machine learning and consumer-resource models.

Evolution of generalists by phenotypic plasticity

This study shows that selection for faster migration in one sugar environment leads to phenotypic plasticity allowing faster migration in all sugars, suggesting plasticity aids in evolving generalist traits.