Suppression of Docetaxel induced apoptosis in Survivin-depleted cells due to failure of sustained mitotic block
This study shows that Survivin depletion in cells leads to evasion of Docetaxel-induced mitotic block and apoptosis, increasing mitotic catastrophe and senescence, thereby enhancing drug efficacy.
bioRxiv · Nov 7, 2019 · PreprintCancer Biology