H. Qi

The discovery of antimicrobial peptides from the gut microbiome of cockroach Blattella germanica using deep learning pipeline

The paper develops a deep learning pipeline to identify antimicrobial peptides from the gut microbiome of Blattella germanica, finding two AMPs with low toxicity and antimicrobial activity.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems

The paper describes the spontaneous formation of peptide-based nanocapsules through a solvent gradient-driven self-assembly process, offering a new approach for drug delivery systems.

Low- and high-grade glioma endothelial cells differentially regulate tumor growth

This study compares tumor endothelial cells from low-grade and high-grade gliomas, finding they have distinct molecular profiles and functional roles in regulating tumor growth.

High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function

This study shows that ZFP318 regulates mitochondrial function in memory B cells, enhancing their recallability and vaccine potency.

An Interleukin 9-Zbtb18 axis promotes germinal center development of memory B cells

This study identifies an Il-9-Zbtb18 axis that promotes the development of memory B cells from germinal centers by regulating cell cycle, survival, and GC exit.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

Disordered climate threatens short-distance migrants

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

mTORC2 contributes to murine systemic autoimmunity

This study shows mTORC2 promotes Tfh differentiation and disrupts Treg homeostasis, contributing to systemic autoimmunity, and suggests mTORC2 as a potential therapeutic target.

scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a

The paper uses scATAC-seq to identify epigenetic heterogeneity in male germline stem cells associated with an EMT-like process and shows G9a regulates this process.

What determines the FDC polarization and GC size in affinity maturation

The paper establishes a spatiotemporal stochastic model to simulate GC self-organization and finds that GC size and structure influence affinity maturation and antibody production.

Qualitative and quantitative bioanalytical methods validation of aristolochic acid DNA adducts and application in human formalin-fixed paraffin-embedded hepatocellular carcinoma tissues

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

Simultaneously monitoring aquatic and riparian biodiversity using riverine water eDNA

This study assesses the effectiveness of riverine water eDNA for monitoring aquatic and riparian biodiversity, finding it effective for detecting species and bioinformation in specific conditions.

Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run

This paper introduces AbMap, a high-throughput epitope mapping technology that identifies epitopes for over 200 antibodies in a single run, including 14 anti-PD-1 antibodies.

Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia

This study shows that TXNIP mediates ER stress-induced NLRP3 inflammasome activation, leading to IL-1β production in preeclampsia.

Contrasting determinants of mutation rates in germline and soma

The paper compares mutation rate determinants in germline and somatic tissues, finding shared factors but contrasting effects of expression levels on mutation rates in ovaries/testes versus tumors.