E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer
G. C. Russo, A. J. Crawford, D. J. Clark, J. Cui, R. Carney, M. N. Karl, B. Su, B. A. Starich, T.-S. Lih, P. Kamat, Q. Zhang, P.-h. Wu, M.-H. Lee, H. S. Leong, V. W. Rebecca, , D. Wirtz
This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.
bioRxiv · Nov 4, 2020Cancer Biology