A. J. Crawford

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

This study shows tumor proliferation and invasion are linked through cell-ECM friction, using in vitro and computational models to demonstrate the role of E-cadherin and matrix properties.

The paper shows how amino acid insertions and substitutions in Na+,K+-ATPase affect toxin resistance in different vertebrate lineages through epistatic interactions.

The paper investigates how intramolecular epistasis affects the evolution of CTS-resistant Na,K-ATPases, finding that resistance substitutions have pleiotropic effects independent of sequence divergence.

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

The paper shows that selection maintains adaptive division-of-labor between tandem duplicates of ATP1A1 in frogs, countering gene conversion to confer toxin resistance.

The paper evaluates the role of Andean uplift versus climate in driving divergence of tetrapod lineages, finding divergence times too recent and asynchronous to support uplift as a primary driver.

This study sequenced the capybara genome to investigate the genetic basis of gigantism and related tradeoffs, finding elevated mutation load and novel anticancer mechanisms.