Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor
C. Guan, Y. Niu, S.-C. Chen, Y. Kang, J.-X. Wu, K. Nishi, C. C. Y. Chang, T.-Y. Chang, T. Luo, L. Chen
This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.
bioRxiv · Jan 7, 2020 · PreprintBiochemistry