J.-X. Wu

Structure of human phagocyte NADPH oxidase in the resting state

The paper reports the cryo-EM structure of the human NOX2-p22 complex in the resting state, revealing interactions and conformational features important for its function.

Structural insights into the high selectivity of the anti-diabetic drug mitiglinide

The paper determines the cryo-EM structure of the SUR1 subunit bound to mitiglinide, revealing its binding site and mechanism of high selectivity.

Structural insights into the mechanism of nucleotide regulation of pancreatic KATP channel

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

Structure and mechanism of human dual oxidase 1 complex

This study reports cryo-EM structures of the human DUOX1-DUOXA1 complex in different calcium states, revealing structural features and calcium regulation of its catalytic activity.

Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex

The paper reports the cryo-EM structure of the NALCN-FAM155A complex, revealing its sodium selectivity, voltage modulation, and disease-related mutation sites.

Structural basis for human TRPC5 channel inhibition by two distinct inhibitors

The paper determines cryo-EM structures of human TRPC5 channel with two inhibitors, revealing their distinct binding sites and mechanisms of action.

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

Structural insights into the mechanism of the human soluble guanylate cyclase

This study reports cryo-EM structures of human sGC 1β1 heterodimer in different states, revealing the structural mechanism of NO-induced activation.

Structure of the receptor-activated human TRPC6 ion channel

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.

Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

The paper presents three cryo-EM structures of pancreatic KATP channels, revealing drug binding sites, subunit interactions, and conformational changes related to metabolic regulation.