T. Luo

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Field dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

Droplet microfluidics forward for tracing target cells at single-cell transcriptome resolution

This paper develops a droplet-based method for single-cell transcriptome profiling of TCR-T cells, improving recovery and reducing contamination.

Linear Mixed-effects model to quantify the association between somatic cell count and milk production in Italian dairy herds

This study uses a mixed-effects model to quantify the negative association between somatic cell count and milk production in Italian dairy herds, finding a 0.830 kg/cow/day loss per two-fold increase in SCC.

Ratiometric 4Pi single molecule localization with optimal resolution and color assignment

This paper introduces a ratiometric multi-color imaging strategy for 4Pi-SMLM that achieves optimal 3D resolution and color separation with minimal loss of localization precision.

Ferroptosis assassinates tumor (FAST)

The paper develops FAST, an improved gene-interfered ferroptosis therapy that shows enhanced antitumor activity and tumor eradication compared to its predecessor GIFT.

Repeated introduction of micropollutants enhances microbial succession despite stable degradation patterns

The paper examines how repeated micropollutant exposure affects microbial community succession and degradation patterns in freshwater systems.

Resolving the graft ischemia-reperfusion injury during liver transplantation at the single cell resolution

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

Role and Dynamics of Vacuolar pH during Cell-in-Cell mediated Death

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

SARS-CoV-2 and Malayan pangolin coronavirus infect human endoderm, ectoderm and induced lung progenitor cells

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

CRISPR-Assisted DNA Detection, a novel dCas9-based DNA detection technique

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

Gene interfered-ferroptosis therapy of cancer

This paper develops a novel cancer therapy called gene interfered-ferroptosis therapy (GIFT) that selectively induces ferroptosis in cancer cells while sparing normal cells.

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

OR1D2 receptor mediates bourgeonal-induced human CatSper activation in a G-protein dependent manner

This study shows that the OR1D2 receptor mediates bourgeonal-induced CatSper activation through a G-protein-cAMP pathway in human sperm.

Spectrin is a mechanoresponsive protein shaping the architecture of intercellular invasion

The paper shows spectrin dynamically accumulates at fusogenic synapses in response to shear deformation, forming a sieve-like network that promotes cell membrane fusion during intercellular invasion.