Tarunya Rao Sudarshan

This paper develops a detergent-free method to produce Aβ42 oligomers compatible with solid-state NMR and shows they induce stronger microglial inflammation than monomers.

This study investigates how deamidation at Q15 or N27 in Aβ-42 affects its aggregation and microglial immune response, finding reduced inflammation and altered CD68 expression.

The paper designs 7-mer peptides that self-assemble into parallel β-sheets using computational screening, simulations, and experimental validation.