Cancer BiologyOncogenePeer-reviewed
PROTAC-Mediated Targeting of IKKβ and NR4A1 for AML Therapy
Chandra Kumar Maharjan, Yi Liu, Yufeng Xiao…·Weizhou Zhang
This paper identifies IKKβ and NR4A1 as drivers of AML and develops a PROTAC to degrade them, showing potent cytotoxicity and reduced leukemia progression in mice.
DOI 10.1038/s41388-026-03925-3