PhysiologyJournal of the American Society of NephrologyPeer-reviewed
Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice
Xue‐Ping Wang, Stephanie M. Mutchler, Rolando Carrisoza‐Gaytan…·Ossama B. Kashlan
This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.