BiochemistrybioRxivPreprint
The immunosuppressant tacrolimus (FK506) inhibits C. glabrata Cdr1 efflux pump function by stabilizing the inward-facing conformation.
Rim Baccouch, Theo Benefice, Eleftherios Zarkadas…·Vincent Chaptal
This paper reveals that tacrolimus inhibits C. glabrata Cdr1 by stabilizing its inward-facing conformation, blocking ATP hydrolysis and azole transport.