BiophysicsbioRxiv
A parametrized two-domain thermodynamic model explains diverse mutational effects on protein allostery
Zhuang Liu, Thomas G Gillis, Srivatsan Raman, Qiang Cui
This study develops a two-domain thermodynamic model to explain mutational effects on protein allostery in TetR, revealing intra- and inter-domain interactions and epistasis.
DOI 10.7554/elife.92262.3