Qiang Cui

The paper investigates ion permeation through a hydrophobic pore formed by the MERS-CoV E protein, revealing that counterions, polarization, and pore hydration collectively enable efficient ion transport.

The paper shows that Erv14/cornichon receptor dynamics and bilayer thickness influence directional ER-Golgi traffic through a mechanism called HEIST.

This paper develops a small molecule, BRD8833, that induces BCR-ABL phosphorylation to disrupt its active site electric field, leading to loss of hyperactivity and apoptosis in BCR-ABL-dependent cancer cells.

This study combines experiments and simulations to investigate how coacervate-membrane interactions affect membrane morphology and fluidity, showing that anionic lipid content modulates these effects.

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

The paper uses simulations to show that Sec23 and Sec24 act as spacers to determine the shape of COPII-coated membrane buds by dispersing Sar1 protomers.

This study evaluates allostery hotspot mutations in TetR using molecular dynamics simulations to understand their effects on allosteric coupling and functional free energy landscapes.

This study shows that the juxtamembrane linker of synaptotagmin 1 mediates liquid-liquid phase separation, which modulates Ca2+ binding and synaptic vesicle exocytosis.

This study investigates how anionic membranes and air-water interfaces affect the stability of FUS-LC fibrils, showing increased stability at these interfaces.

This study develops a two-domain thermodynamic model to explain mutational effects on protein allostery in TetR, revealing intra- and inter-domain interactions and epistasis.

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

This study compares synaptotagmin-1 and synaptotagmin-7, finding that synaptotagmin-7 more effectively penetrates membranes and stabilizes fusion pores during exocytosis.

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.