Tong Zhu

RNARL is a reinforcement learning framework for RNA codon design that generates high-performance sequences across multiple species and RNA types.

DeepSAP improves RNA-seq alignment by combining transcriptome-guided alignment with a transformer-based model for splice junction scoring, achieving the highest F1 score on simulated datasets.

This paper introduces time-resolved fluorescent proteins (TRFPs) that enable temporal-spectral resolved microscopy for multiplexed imaging and super-resolution in live cells.

Parabricks accelerates genomic analysis using GPU acceleration, reducing processing time while maintaining accuracy across various sequencing modalities.

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

The paper introduces MuSE2.0, a tool that accelerates somatic mutation calling for whole-genome and whole-exome sequencing data from heterogeneous tumor samples, achieving significant speed improvements over existing methods.

This study shows that newly regenerated inner hair cells in the cochlea lack functional mechanosensory transduction, preventing hearing recovery despite successful cell regeneration.

This study identifies Tbx2 as essential for inner hair cell development and shows that its co-expression with Atoh1 can reprogram supporting cells into functional inner hair cells.